Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023)

Allosteric Activation of Transglutaminase 2 Transglutaminase 2 (TGM2) serves as a cellular target of small molecule forskolin to promote osteoblast differentiation and ameliorate ovariectomy‐induced osteoporosis. Forskolin binds to TGM2 on a previously undisclosed allosteric site to activate TGM2 by...

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Detalles Bibliográficos
Autores principales: Yang, Zhuo, Zhang, Xiao‐Wen, Zhuo, Fang‐Fang, Liu, Ting‐Ting, Luo, Qian‐Wei, Zheng, Yong‐Zhe, Li, Ling, Yang, Heng, Zhang, Yi‐Chi, Wang, Yan‐Hang, Liu, Dan, Tu, Peng‐Fei, Zeng, Ke‐Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288254/
http://dx.doi.org/10.1002/advs.202370117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288254/
http://dx.doi.org/10.1002/advs.202370117

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