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Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023)
Allosteric Activation of Transglutaminase 2 Transglutaminase 2 (TGM2) serves as a cellular target of small molecule forskolin to promote osteoblast differentiation and ameliorate ovariectomy‐induced osteoporosis. Forskolin binds to TGM2 on a previously undisclosed allosteric site to activate TGM2 by...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288254/ http://dx.doi.org/10.1002/advs.202370117 |
| _version_ | 1785062043114536960 |
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| author | Yang, Zhuo Zhang, Xiao‐Wen Zhuo, Fang‐Fang Liu, Ting‐Ting Luo, Qian‐Wei Zheng, Yong‐Zhe Li, Ling Yang, Heng Zhang, Yi‐Chi Wang, Yan‐Hang Liu, Dan Tu, Peng‐Fei Zeng, Ke‐Wu |
| author_facet | Yang, Zhuo Zhang, Xiao‐Wen Zhuo, Fang‐Fang Liu, Ting‐Ting Luo, Qian‐Wei Zheng, Yong‐Zhe Li, Ling Yang, Heng Zhang, Yi‐Chi Wang, Yan‐Hang Liu, Dan Tu, Peng‐Fei Zeng, Ke‐Wu |
| author_sort | Yang, Zhuo |
| collection | PubMed |
| description | Allosteric Activation of Transglutaminase 2 Transglutaminase 2 (TGM2) serves as a cellular target of small molecule forskolin to promote osteoblast differentiation and ameliorate ovariectomy‐induced osteoporosis. Forskolin binds to TGM2 on a previously undisclosed allosteric site to activate TGM2 by inducing an “open” conformation, thereby improving mitochondrial energy metabolism for osteoporosis treatment. More details can be found in article number 2206533 by Ke‐Wu Zeng and co‐workers. [Image: see text] |
| format | Online Article Text |
| id | pubmed-10288254 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-102882542023-06-24 Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023) Yang, Zhuo Zhang, Xiao‐Wen Zhuo, Fang‐Fang Liu, Ting‐Ting Luo, Qian‐Wei Zheng, Yong‐Zhe Li, Ling Yang, Heng Zhang, Yi‐Chi Wang, Yan‐Hang Liu, Dan Tu, Peng‐Fei Zeng, Ke‐Wu Adv Sci (Weinh) Back Cover Allosteric Activation of Transglutaminase 2 Transglutaminase 2 (TGM2) serves as a cellular target of small molecule forskolin to promote osteoblast differentiation and ameliorate ovariectomy‐induced osteoporosis. Forskolin binds to TGM2 on a previously undisclosed allosteric site to activate TGM2 by inducing an “open” conformation, thereby improving mitochondrial energy metabolism for osteoporosis treatment. More details can be found in article number 2206533 by Ke‐Wu Zeng and co‐workers. [Image: see text] John Wiley and Sons Inc. 2023-06-23 /pmc/articles/PMC10288254/ http://dx.doi.org/10.1002/advs.202370117 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Back Cover Yang, Zhuo Zhang, Xiao‐Wen Zhuo, Fang‐Fang Liu, Ting‐Ting Luo, Qian‐Wei Zheng, Yong‐Zhe Li, Ling Yang, Heng Zhang, Yi‐Chi Wang, Yan‐Hang Liu, Dan Tu, Peng‐Fei Zeng, Ke‐Wu Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023) |
| title | Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023) |
| title_full | Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023) |
| title_fullStr | Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023) |
| title_full_unstemmed | Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023) |
| title_short | Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023) |
| title_sort | allosteric activation of transglutaminase 2 via inducing an “open” conformation for osteoblast differentiation (adv. sci. 18/2023) |
| topic | Back Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288254/ http://dx.doi.org/10.1002/advs.202370117 |
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