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Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions

[Image: see text] Enzymes are of central importance to many biotechnological and biomedical applications. However, for many potential applications, the required conditions impede enzyme folding and therefore function. The enzyme Sortase A is a transpeptidase that is widely used to perform bioconjuga...

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Detalles Bibliográficos
Autores principales: Kiehstaller, Sebastian, Hutchins, George H., Amore, Alessia, Gerber, Alan, Ibrahim, Mohamed, Hennig, Sven, Neubacher, Saskia, Grossmann, Tom N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288436/
https://www.ncbi.nlm.nih.gov/pubmed/37246906
http://dx.doi.org/10.1021/acs.bioconjchem.3c00151