Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis

[Image: see text] Alanine racemase (Alr) is a pyridoxal 5′-phosphate-dependent enzyme that catalyzes the racemization of l-alanine to d-alanine. Alr is one of the two targets of the broad-spectrum antibiotic d-cycloserine (DCS), a structural analogue of d-alanine. Despite being an essential componen...

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Detalles Bibliográficos
Autores principales: de Chiara, Cesira, Prosser, Gareth A., Ogrodowicz, Roksana, de Carvalho, Luiz P. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288493/
https://www.ncbi.nlm.nih.gov/pubmed/37363078
http://dx.doi.org/10.1021/acsbiomedchemau.2c00074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288493/
https://www.ncbi.nlm.nih.gov/pubmed/37363078
http://dx.doi.org/10.1021/acsbiomedchemau.2c00074

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