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Catalytic Site Proximity Profiling for Functional Unification of Sequence-Diverse Radical S-Adenosylmethionine Enzymes

[Image: see text] The radical S-adenosylmethionine (rSAM) superfamily has become a wellspring for discovering new enzyme chemistry, especially regarding ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, we report a compendium of nearly 15,000 rSAM proteins with high-c...

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Detalles Bibliográficos
Autores principales: Precord, Timothy W., Ramesh, Sangeetha, Dommaraju, Shravan R., Harris, Lonnie A., Kille, Bryce L., Mitchell, Douglas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288494/
https://www.ncbi.nlm.nih.gov/pubmed/37363077
http://dx.doi.org/10.1021/acsbiomedchemau.2c00085