Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells

T cell antigen receptor stimulation induces tyrosine phosphorylation of downstream signaling molecules and the phosphatidylinositol, Ras, MAPK, and PI3 kinase pathways, leading to T cell activation. Previously, we reported that the G-protein-coupled human muscarinic receptor could bypass tyrosine ki...

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Detalles Bibliográficos
Autores principales: Nguyen, Trang T. T., Lu, Wen, Zhu, Wandi S., Ansel, K. Mark, Liang, Hong-Erh, Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288620/
https://www.ncbi.nlm.nih.gov/pubmed/37307442
http://dx.doi.org/10.1073/pnas.2300987120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288620/
https://www.ncbi.nlm.nih.gov/pubmed/37307442
http://dx.doi.org/10.1073/pnas.2300987120

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