Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

The polymorphic nature and intrinsic instability of class I major histocompatibility complex (MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, or glycolipids presents a fundamental challenge for identifying disease-relevant antigens and antigen-specific T cell receptors (T...

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Detalles Bibliográficos
Autores principales: Sun, Yi, Young, Michael C., Woodward, Claire H., Danon, Julia N., Truong, Hau V., Gupta, Sagar, Winters, Trenton J., Font-Burgada, Joan, Burslem, George M., Sgourakis, Nikolaos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288639/
https://www.ncbi.nlm.nih.gov/pubmed/37310998
http://dx.doi.org/10.1073/pnas.2304055120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288639/
https://www.ncbi.nlm.nih.gov/pubmed/37310998
http://dx.doi.org/10.1073/pnas.2304055120

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