PD-1 blockade attenuates surgery-mediated immunosuppression and boosts Th1 immunity perioperatively in oesophagogastric junctional adenocarcinoma

INTRODUCTION: This timely study assesses the immunosuppressive effects of surgery on cytotoxic Th1-like immunity and investigates if immune checkpoint blockade (ICB) can boost Th1-like immunity in the perioperative window in upper gastrointestinal cancer (UGI) patients. METHODS: PBMCs were isolated...

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Detalles Bibliográficos
Autores principales: Davern, Maria, Gaughan, Caoimhe, O’ Connell, Fiona, Moran, Brendan, Mylod, Eimear, Sheppard, Andrew D., Ramjit, Sinead, Yun-Tong Kung, Jasmine, Phelan, James J., Davey, Matthew G., Ryan, Eanna J., Butler, Christine, Quinn, Laura, Howard, Claudine, Tone, Emily, Phoenix, Eimear, Butt, Waqas T., Lynam-Lennon, Niamh, Maher, Stephen G., Ravi, Narayanasamy, Donohoe, Claire L., Reynolds, John V., Lysaght, Joanne, Donlon, Noel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288841/
https://www.ncbi.nlm.nih.gov/pubmed/37359545
http://dx.doi.org/10.3389/fimmu.2023.1150754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288841/
https://www.ncbi.nlm.nih.gov/pubmed/37359545
http://dx.doi.org/10.3389/fimmu.2023.1150754

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