Cargando…

Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1

INTRODUCTION: The emergency use of vaccines has been the most efficient way to control the coronavirus disease 19 (COVID-19) pandemic. However, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern has reduced the efficacy of currently used vaccines. The r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonzalez-Hernandez, Mariana, Kaiser, Franziska Karola, Steffen, Imke, Ciurkiewicz, Malgorzata, van Amerongen, Geert, Tchelet, Ronen, Emalfarb, Mark, Saloheimo, Markku, Wiebe, Marilyn G., Vitikainen, Marika, Albulescu, Irina C., Bosch, Berend-Jan, Baumgärtner, Wolfgang, Haagmans, Bart L., Osterhaus, Albert D. M. E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289020/ https://www.ncbi.nlm.nih.gov/pubmed/37359531 http://dx.doi.org/10.3389/fimmu.2023.1204834

Ejemplares similares

Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform
por: Ramot, Yuval, et al.
Publicado: (2022)

The Highly Productive Thermothelomyces heterothallica C1 Expression System as a Host for Rapid Development of Influenza Vaccines
por: Keresztes, Gabor, et al.
Publicado: (2022)

A recombinant SARS-CoV-2 receptor-binding domain expressed in an engineered fungal strain of Thermothelomyces heterothallica induces a functional immune response in mice
por: Lazo, Laura, et al.
Publicado: (2022)

Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel(®)85 Protects K18-hACE2 Mice against Lethal Virus Challenge
por: Nechooshtan, Ram, et al.
Publicado: (2022)

Development of a Modular Vaccine Platform for Multimeric Antigen Display Using an Orthobunyavirus Model
por: Aebischer, Andrea, et al.
Publicado: (2021)

Sexual crossing of thermophilic fungus Myceliophthora heterothallica improved enzymatic degradation of sugar beet pulp
por: Aguilar-Pontes, Maria Victoria, et al.
Publicado: (2016)

Array comparative genomic hybridization analysis of Trichoderma reesei strains with enhanced cellulase production properties
por: Vitikainen, Marika, et al.
Publicado: (2010)

Transcriptomic insights into the roles of the transcription factors Clr1, Clr2 and Clr4 in lignocellulose degradation of the thermophilic fungal platform Thermothelomyces thermophilus
por: Siebecker, Benedikt, et al.
Publicado: (2023)

Engineered Fungus Thermothelomyces thermophilus Producing Plant Storage Proteins
por: Balabanova, Larissa, et al.
Publicado: (2022)

Effect of pH, Temperature, and Chemicals on the Endoglucanases and β-Glucosidases from the Thermophilic Fungus Myceliophthora heterothallica F.2.1.4. Obtained by Solid-State and Submerged Cultivation
por: Teixeira da Silva, Vanessa de Cássia, et al.
Publicado: (2016)

Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas
por: Rodon, Jordi, et al.
Publicado: (2022)

Screening of candidate regulators for cellulase and hemicellulase production in Trichoderma reesei and identification of a factor essential for cellulase production
por: Häkkinen, Mari, et al.
Publicado: (2014)

Optimization of Transesterification Reactions with CLEA-Immobilized Feruloyl Esterases from Thermothelomyces thermophila and Talaromyces wortmannii
por: Zerva, Anastasia, et al.
Publicado: (2018)

SARS-CoV-2 (B1.1.529) Omicron variant: what has changed in the nose?
por: Ciurkiewicz, M., et al.
Publicado: (2023)

Identification of Thermostable Xylose Reductase from Thermothelomyces thermophilus: A Biochemical Characterization Approach to Meet Biofuel Challenges
por: Ali, Nabeel, et al.
Publicado: (2022)

Characterization of a novel AA3_1 xylooligosaccharide dehydrogenase from Thermothelomyces myriococcoides CBS 398.93
por: Zhao, Hongbo, et al.
Publicado: (2022)

SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters
por: Armando, Federico, et al.
Publicado: (2022)

Transcriptional monitoring of steady state and effects of anaerobic phases in chemostat cultures of the filamentous fungus Trichoderma reesei
por: Rautio, Jari J, et al.
Publicado: (2006)

Detection of double-stranded RNA intermediates of four major SARS-CoV-2 variants in formalin-fixed paraffin-embedded lung tissue of Syrian golden hamsters using monoclonal antibodies
por: Beythien, G., et al.
Publicado: (2023)

Zoonoses Anticipation and Preparedness Initiative, stakeholders conference, February 4 & 5, 2021
por: Beer, Martin, et al.
Publicado: (2021)

In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum
por: Espinosa, Luis Ariel, et al.
Publicado: (2021)

Safety evaluation of a β-mannanase enzyme preparation produced with Thermothelomyces thermophilus expressing a protein-engineered β-mannanase gene
por: Kern, Andreas, et al.
Publicado: (2020)

Structure–function studies of a novel laccase-like multicopper oxidase from Thermothelomyces thermophila provide insights into its biological role
por: Kosinas, Christos, et al.
Publicado: (2023)

Molecular characterization of a bovine adenovirus type 7 (Bovine Atadenovirus F) strain isolated from a systemically infected calf in Germany
por: Jesse, Sonja T., et al.
Publicado: (2022)

Correlation of gene expression and protein production rate - a system wide study
por: Arvas, Mikko, et al.
Publicado: (2011)

Anaerobic Thermophiles
por: Canganella, Francesco, et al.
Publicado: (2014)

Secreted fungal sulfhydryl oxidases: sequence analysis and characterisation of a representative flavin-dependent enzyme from Aspergillus oryzae
por: Faccio, Greta, et al.
Publicado: (2010)

Comparison of intracellular and secretion-based strategies for production of human α-galactosidase A in the filamentous fungus Trichoderma reesei
por: Smith, Wesley, et al.
Publicado: (2014)

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern
por: Du, Wenjuan, et al.
Publicado: (2022)

The effects of disruption of phosphoglucose isomerase gene on carbon utilisation and cellulase production in Trichoderma reesei Rut-C30
por: Limón, M Carmen, et al.
Publicado: (2011)

A Statistical Analysis of the Sequence and Structure of Thermophilic and Non-Thermophilic Proteins
por: Ahmed, Zahoor, et al.
Publicado: (2022)

Nonhuman Primate Models for SARS
por: Haagmans, Bart L, et al.
Publicado: (2006)

Authors' Response to Hogan
por: Haagmans, Bart L, et al.
Publicado: (2006)

Severe acute respiratory syndrome (SARS) vaccines
por: Haagmans, Bart L., et al.
Publicado: (2008)

Coronaviruses and their therapy
por: Haagmans, Bart L., et al.
Publicado: (2006)

SARS
por: Haagmans, Bart L., et al.
Publicado: (2009)

Discrimination of Thermophilic Proteins and Non-thermophilic Proteins Using Feature Dimension Reduction
por: Guo, Zifan, et al.
Publicado: (2020)

Virogenomics: the virus–host interaction revisited
por: Andeweg, Arno C, et al.
Publicado: (2008)

Predictors of RBD progression and conversion to synucleinopathies
por: de Natale, Edoardo Rosario, et al.
Publicado: (2022)

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2
por: Sun, Shiyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_glalm8las6tm2i6vitpha0ibst