Reduced levels of ALS gene DCTN1 induce motor defects in Drosophila

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neuromuscular disease that has a strong genetic component. Deleterious variants in the DCTN1 gene are known to be a cause of ALS in diverse populations. DCTN1 encodes the p150 subunit of the molecular motor dynactin which is a key player i...

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Detalles Bibliográficos
Autores principales: Borg, Rebecca, Herrera, Paul, Purkiss, Angie, Cacciottolo, Rebecca, Cauchi, Ruben J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289029/
https://www.ncbi.nlm.nih.gov/pubmed/37360176
http://dx.doi.org/10.3389/fnins.2023.1164251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289029/
https://www.ncbi.nlm.nih.gov/pubmed/37360176
http://dx.doi.org/10.3389/fnins.2023.1164251

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