Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection

BACKGROUND: Optineurin (OPTN) is associated with several human diseases, including amyotrophic lateral sclerosis (ALS), and is involved in various cellular processes, including autophagy. Optineurin regulates the expression of interferon beta (IFNβ), which plays a central role in the innate immune r...

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Detalles Bibliográficos
Autores principales: Fukushi, Masaya, Ohsawa, Ryosuke, Okinaka, Yasushi, Oikawa, Daisuke, Kiyono, Tohru, Moriwaki, Masaya, Irie, Takashi, Oda, Kosuke, Kamei, Yasuhiro, Tokunaga, Fuminori, Sotomaru, Yusuke, Maruyama, Hirofumi, Kawakami, Hideshi, Sakaguchi, Takemasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289332/
https://www.ncbi.nlm.nih.gov/pubmed/37352136
http://dx.doi.org/10.1371/journal.pone.0287545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289332/
https://www.ncbi.nlm.nih.gov/pubmed/37352136
http://dx.doi.org/10.1371/journal.pone.0287545

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