c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer’s disease

BACKGROUND: Growing evidence suggests that the non-receptor tyrosine kinase, c-Abl, plays a significant role in the pathogenesis of Alzheimer’s disease (AD). Here, we analyzed the effect of c-Abl on the cognitive performance decline of APPSwe/PSEN1ΔE9 (APP/PS1) mouse model for AD. METHODS: We used t...

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Detalles Bibliográficos
Autores principales: León, Rilda, Gutiérrez, Daniela A., Pinto, Claudio, Morales, Cristian, de la Fuente, Catalina, Riquelme, Cristóbal, Cortés, Bastián I., González-Martin, Adrián, Chamorro, David, Espinosa, Nelson, Fuentealba, Pablo, Cancino, Gonzalo I., Zanlungo, Silvana, Dulcey, Andrés E., Marugan, Juan J., Álvarez Rojas, Alejandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289333/
https://www.ncbi.nlm.nih.gov/pubmed/37358955
http://dx.doi.org/10.3389/fnagi.2023.1180987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289333/
https://www.ncbi.nlm.nih.gov/pubmed/37358955
http://dx.doi.org/10.3389/fnagi.2023.1180987

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