Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3

Autophagosome biogenesis requires a localized perturbation of lipid membrane dynamics and a unique protein-lipid conjugate. Autophagy-related (ATG) proteins catalyze this biogenesis on cellular membranes, but the underlying molecular mechanism remains unclear. Focusing on the final step of the prote...

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Detalles Bibliográficos
Autores principales: Nishimura, Taki, Lazzeri, Gianmarco, Mizushima, Noboru, Covino, Roberto, Tooze, Sharon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289646/
https://www.ncbi.nlm.nih.gov/pubmed/37352354
http://dx.doi.org/10.1126/sciadv.adh1281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289646/
https://www.ncbi.nlm.nih.gov/pubmed/37352354
http://dx.doi.org/10.1126/sciadv.adh1281

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