VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation

Stringent control of type I interferon (IFN-I) signaling is critical to potent innate immune responses against viral infection, yet the underlying molecular mechanisms are still elusive. Here, we found that Van Gogh–like 2 (VANGL2) acts as an IFN-inducible negative feedback regulator to suppress IFN...

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Detalles Bibliográficos
Autores principales: Hu, Zhiqiang, Xie, Yingchao, Lu, Jiansen, Yang, Jianwu, Zhang, Jiahuan, Jiang, Huaji, Li, Hongyu, Zhang, Yufeng, Wu, Dan, Zeng, Ke, Bai, Xiaochun, Yu, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289648/
https://www.ncbi.nlm.nih.gov/pubmed/37352355
http://dx.doi.org/10.1126/sciadv.adg2339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289648/
https://www.ncbi.nlm.nih.gov/pubmed/37352355
http://dx.doi.org/10.1126/sciadv.adg2339

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