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VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation

Stringent control of type I interferon (IFN-I) signaling is critical to potent innate immune responses against viral infection, yet the underlying molecular mechanisms are still elusive. Here, we found that Van Gogh–like 2 (VANGL2) acts as an IFN-inducible negative feedback regulator to suppress IFN...

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Detalles Bibliográficos
Autores principales:	Hu, Zhiqiang, Xie, Yingchao, Lu, Jiansen, Yang, Jianwu, Zhang, Jiahuan, Jiang, Huaji, Li, Hongyu, Zhang, Yufeng, Wu, Dan, Zeng, Ke, Bai, Xiaochun, Yu, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289648/ https://www.ncbi.nlm.nih.gov/pubmed/37352355 http://dx.doi.org/10.1126/sciadv.adg2339

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