Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis

Basal-like breast cancers (BLBCs) are among the most aggressive cancers, partly due to their enrichment of cancer stem cells (CSCs). Breast CSCs can be generated from luminal-type cancer cells via epithelial-mesenchymal transition (EMT). GATA3 maintains luminal cell fate, and its expression is lost...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xiong, Bai, Feng, Wang, Yuchan, Wang, Chuying, Chan, Ho Lam, Zheng, Chenglong, Fang, Jian, Zhu, Wei-Guo, Pei, Xin-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290069/
https://www.ncbi.nlm.nih.gov/pubmed/37353480
http://dx.doi.org/10.1038/s41419-023-05888-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290069/
https://www.ncbi.nlm.nih.gov/pubmed/37353480
http://dx.doi.org/10.1038/s41419-023-05888-9

Ejemplares similares