TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease

Crosstalk between ion channels and small GTPases is critical during homeostasis and disease, but little is known about the structural underpinnings of these interactions. TRPV4 is a polymodal, calcium-permeable cation channel that has emerged as a potential therapeutic target in multiple conditions....

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Detalles Bibliográficos
Autores principales: Kwon, Do Hoon, Zhang, Feng, McCray, Brett A., Feng, Shasha, Kumar, Meha, Sullivan, Jeremy M., Im, Wonpil, Sumner, Charlotte J., Lee, Seok-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290081/
https://www.ncbi.nlm.nih.gov/pubmed/37353484
http://dx.doi.org/10.1038/s41467-023-39345-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290081/
https://www.ncbi.nlm.nih.gov/pubmed/37353484
http://dx.doi.org/10.1038/s41467-023-39345-0

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