Cargando…

Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21

Increasing energy expenditure through uncoupling protein 1 (UCP1) activity in thermogenic adipose tissue is widely investigated to correct diet-induced obesity (DIO). Paradoxically, UCP1-deficient male mice are resistant to DIO at room temperature. Recently, we uncovered a key role for fibroblast gr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klein Hazebroek, Marlou, Laterveer, Rutger, Kutschke, Maria, Ramšak Marčeta, Vida, Barthem, Clarissa S., Keipert, Susanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290677/ https://www.ncbi.nlm.nih.gov/pubmed/37355753 http://dx.doi.org/10.1038/s41598-023-37264-0

Ejemplares similares

Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue
por: Klein Hazebroek, Marlou, et al.
Publicado: (2022)

Adapting to the Cold: A Role for Endogenous Fibroblast Growth Factor 21 in Thermoregulation?
por: Klein Hazebroek, Marlou, et al.
Publicado: (2020)

Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
por: Keipert, Susanne, et al.
Publicado: (2020)

Author Correction: Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
por: Keipert, Susanne, et al.
Publicado: (2021)

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
por: Keipert, Susanne, et al.
Publicado: (2015)

A pyrexic effect of FGF21 independent of energy expenditure and UCP1
por: Zouhar, Petr, et al.
Publicado: (2021)

Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain
por: Lee, Shin J., et al.
Publicado: (2020)

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis
por: Cavalieri, Riccardo, et al.
Publicado: (2022)

Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints
por: Hill, Cristal M., et al.
Publicado: (2017)

FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
por: Shamsi, Farnaz, et al.
Publicado: (2020)

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
por: Masania, Jinit, et al.
Publicado: (2022)

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action
por: Ost, Mario, et al.
Publicado: (2015)

Food Intake and Hypothalamic Hyperphagia
por: Strominger, Jack L., et al.
Publicado: (1953)

FGF21 contributes to neuroendocrine control of female reproduction
por: Owen, Bryn M., et al.
Publicado: (2013)

Experimental Hypothalamic Hyperphagia in the Albino Rat
por: Brobeck, John R., et al.
Publicado: (1943)

The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis
por: Antonellis, Patrick J., et al.
Publicado: (2019)

FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
por: Chen, Mark Z., et al.
Publicado: (2017)

FGF19 subfamily members: FGF19 and FGF21
por: Dolegowska, Katarzyna, et al.
Publicado: (2019)

Hyperphagia, Growth, and Puberty in Children with Angelman Syndrome
por: Bindels-de Heus, Karen G. C. B., et al.
Publicado: (2023)

Estradiol-dependent and independent effects of FGF21 in obese female mice
por: Jakovleva, T.V., et al.
Publicado: (2022)

FGF21 negatively affects long-term female fertility in mice
por: Moeckli, Beat, et al.
Publicado: (2022)

A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity
por: Geisler, Caroline E., et al.
Publicado: (2021)

High-fat diet accelerates extreme obesity with hyperphagia in female heterozygous Mecp2-null mice
por: Fukuhara, Shota, et al.
Publicado: (2019)

Hypermetabolism, Hyperphagia, and Reduced Adiposity in Tankyrase-Deficient Mice
por: Yeh, Tsung-Yin J., et al.
Publicado: (2009)

Myostatin inhibition improves hyperglycemia and hyperphagia in lipodystrophic mice
por: Guo, Tingqing, et al.
Publicado: (2012)

Hemiballismus, Hyperphagia, and Behavioral Changes following Subthalamic Infarct
por: Etemadifar, Masoud, et al.
Publicado: (2012)

Behavioral Characterization of the Hyperphagia Synphilin-1 Overexpressing Mice
por: Li, Xueping, et al.
Publicado: (2014)

Adipocyte OGT governs diet-induced hyperphagia and obesity
por: Li, Min-Dian, et al.
Publicado: (2018)

Stress-induced hyperphagia: empirical characterization of stress-overeaters
por: Kaiser, Birgit, et al.
Publicado: (2022)

FGF19 and FGF21: In NASH we trust
por: Talukdar, Saswata, et al.
Publicado: (2020)

FGF21 and Cardiac Physiopathology
por: Planavila, Anna, et al.
Publicado: (2015)

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
por: Adams, Andrew C., et al.
Publicado: (2012)

FGF19 and FGF21 for the Treatment of NASH—Two Sides of the Same Coin? Differential and Overlapping Effects of FGF19 and FGF21 From Mice to Human
por: Henriksson, Emma, et al.
Publicado: (2020)

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
por: Villarroya, Joan, et al.
Publicado: (2018)

Involvement of inflammatory gene expression pathways in depressed patients with hyperphagia
por: de Kluiver, Hilde, et al.
Publicado: (2019)

Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid: Relationship With Plasma FGF21 and Body Adiposity
por: Tan, Bee K., et al.
Publicado: (2011)

Moxibustion-Simulating Bipolar Radiofrequency Suppresses Weight Gain and Induces Adipose Tissue Browning via Activation of UCP1 and FGF21 in a Mouse Model of Diet-Induced Obesity
por: Koh, Young Jun, et al.
Publicado: (2018)

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases
por: Kim, Kook Hwan, et al.
Publicado: (2014)

Head Over Hepatocytes for FGF21
por: Potthoff, Matthew J., et al.
Publicado: (2014)

THE EFFECT OF HYPERGLYCEMIA ON HYPOTHALAMIC GOLD UPTAKE AND HYPERPHAGIA IN GOLDTHIOGLUCOSE-TREATED MICE
por: Edelman, P. Michael, et al.
Publicado: (1965)

Cannot write session to /tmp/vufind_sessions/sess_k7ohn0ti73u8dp38ts92nvktt0