Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids

De novo mutations and copy number deletions in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). It is unclear how NRXN1 deletions impact cortical development in a cell type-specific manner and disease background modulates these phenotypes. Here, we leveraged human pluripotent stem cel...

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Detalles Bibliográficos
Autores principales: Sebastian, Rebecca, Jin, Kang, Pavon, Narciso, Bansal, Ruby, Potter, Andrew, Song, Yoonjae, Babu, Juliana, Gabriel, Rafael, Sun, Yubing, Aronow, Bruce, Pak, ChangHui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290702/
https://www.ncbi.nlm.nih.gov/pubmed/37355690
http://dx.doi.org/10.1038/s41467-023-39420-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290702/
https://www.ncbi.nlm.nih.gov/pubmed/37355690
http://dx.doi.org/10.1038/s41467-023-39420-6

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