A Steric “Ball-and-Chain” Mechanism for pH-Mediated Regulation of Gap Junction Channels

Gap junction channels (GJCs) mediate intercellular communication and are gated by numerous conditions such as pH. The electron cryomicroscopy (cryo-EM) structure of Cx26 GJC at physiological pH recapitulates previous GJC structures in lipid bilayers. At pH 6.4, we identify two conformational states,...

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Detalles Bibliográficos
Autores principales: Khan, Ali K., Jagielnicki, Maciej, McIntire, William E., Purdy, Michael D., Dharmarajan, Venkatasubramanian, Griffin, Patrick R., Yeager, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290761/
https://www.ncbi.nlm.nih.gov/pubmed/32320665
http://dx.doi.org/10.1016/j.celrep.2020.03.046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290761/
https://www.ncbi.nlm.nih.gov/pubmed/32320665
http://dx.doi.org/10.1016/j.celrep.2020.03.046

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