Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition

BMS906024, a γ-secretase inhibitor that blocks Notch signaling, was previously shown to inhibit Cryptosporidium parvum growth in vitro. A structure–activity relationship (SAR) analysis of BMS906024 reported herein demonstrates the importance of the stereochemistry of the C-3 benzodiazepine and the s...

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Detalles Bibliográficos
Autores principales: Lee, Seungheon, Love, Melissa S., Modukuri, Ramkumar, Chatterjee, Arnab K., Huerta, Lauren, Lawson, Ann P., McNamara, Case W., Mead, Jan R., Hedstrom, Lizbeth, Cuny, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290938/
https://www.ncbi.nlm.nih.gov/pubmed/37196868
http://dx.doi.org/10.1016/j.bmcl.2023.129328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290938/
https://www.ncbi.nlm.nih.gov/pubmed/37196868
http://dx.doi.org/10.1016/j.bmcl.2023.129328

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