The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) mediate insulin responses that are proportionate to nutrient intake to facilitate glucose tolerance(1). The GLP-1 receptor (GLP-1R) is an established drug target for the treatment of diabetes and obe...

Descripción completa

Detalles Bibliográficos
Autores principales: El, Kimberley, Douros, Jonathan D., Willard, Francis S., Novikoff, Aaron, Sargsyan, Ashot, Perez-Tilve, Diego, Wainscott, David B., Yang, Bin, Chen, Alex, Wothe, Donald, Coupland, Callum, Tschöp, Mattias H., Finan, Brian, D’Alessio, David A., Sloop, Kyle W., Müller, Timo D., Campbell, Jonathan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290954/
https://www.ncbi.nlm.nih.gov/pubmed/37277609
http://dx.doi.org/10.1038/s42255-023-00811-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290954/
https://www.ncbi.nlm.nih.gov/pubmed/37277609
http://dx.doi.org/10.1038/s42255-023-00811-0

Ejemplares similares