TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance

Immune checkpoint blockade (ICB) offers a new opportunity for treatment for gastric cancer (G.C.). Understanding the upstream regulation of immune checkpoints is crucial to further improve the efficacy of ICB therapy. Herein, using the CRISPR-Cas9-based genome-wide screening, we identified TRIM28 as...

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Detalles Bibliográficos
Autores principales: Ma, Xiaoxiao, Jia, Shuqin, Wang, Gangjian, Liang, Min, Guo, Ting, Du, Hong, Li, Sisi, Li, Xiaomei, Huangfu, Longtao, Guo, Jianping, Xing, Xiaofang, Ji, Jiafu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290989/
https://www.ncbi.nlm.nih.gov/pubmed/37357254
http://dx.doi.org/10.1038/s41392-023-01450-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290989/
https://www.ncbi.nlm.nih.gov/pubmed/37357254
http://dx.doi.org/10.1038/s41392-023-01450-3

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