Cargando…

TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance

Immune checkpoint blockade (ICB) offers a new opportunity for treatment for gastric cancer (G.C.). Understanding the upstream regulation of immune checkpoints is crucial to further improve the efficacy of ICB therapy. Herein, using the CRISPR-Cas9-based genome-wide screening, we identified TRIM28 as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Xiaoxiao, Jia, Shuqin, Wang, Gangjian, Liang, Min, Guo, Ting, Du, Hong, Li, Sisi, Li, Xiaomei, Huangfu, Longtao, Guo, Jianping, Xing, Xiaofang, Ji, Jiafu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290989/ https://www.ncbi.nlm.nih.gov/pubmed/37357254 http://dx.doi.org/10.1038/s41392-023-01450-3

Ejemplares similares

Novel prognostic marker LINC00205 promotes tumorigenesis and metastasis by competitively suppressing miRNA-26a in gastric cancer
por: Huangfu, Longtao, et al.
Publicado: (2022)

SDCBP‐AS1 destabilizes β‐catenin by regulating ubiquitination and SUMOylation of hnRNP K to suppress gastric tumorigenicity and metastasis
por: Han, Jing, et al.
Publicado: (2022)

CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways
por: Han, Jing, et al.
Publicado: (2021)

CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways: Erratum
por: Han, Jing, et al.
Publicado: (2023)

TNFRSF11B activates Wnt/β-catenin signaling and promotes gastric cancer progression
por: Luan, Fengming, et al.
Publicado: (2020)

Characterization of glycometabolism and tumor immune microenvironment for predicting clinical outcomes in gastric cancer
por: Shi, Jinyao, et al.
Publicado: (2023)

MicroRNA-135b/CAMK2D Axis Contribute to Malignant Progression of Gastric Cancer through EMT Process Remodeling
por: Huangfu, Longtao, et al.
Publicado: (2021)

Transcriptome profiling of patient-derived tumor xenografts suggests novel extracellular matrix-related signatures for gastric cancer prognosis prediction
por: Deng, Ziqian, et al.
Publicado: (2023)

Genome trimming by Borna disease viruses: Viral replication control or escape from cellular surveillance?
por: Schneider, U., et al.
Publicado: (2007)

Mapping the interaction between Trim28 and the KRAB domain at the center of Trim28 silencing of endogenous retroviruses
por: Taka, Jamie R. H., et al.
Publicado: (2022)

The complexity of TRIM28 contribution to cancer
por: Czerwińska, Patrycja, et al.
Publicado: (2017)

Expression and Significance of TRIM 28 in Squamous Carcinoma of Esophagus
por: Liu, Bo, et al.
Publicado: (2018)

TRIM28 is overexpressed in glioma and associated with tumor progression
por: Su, Chunhai, et al.
Publicado: (2018)

TRIM28 variants and Wilms' tumour predisposition
por: Hol, Janna A, et al.
Publicado: (2021)

TRIM28 as a novel transcriptional elongation factor
por: Bunch, Heeyoun, et al.
Publicado: (2015)

TRIM28 Regulates Dlk1 Expression in Adipogenesis
por: Lu, Hsin-Pin, et al.
Publicado: (2020)

T‐cells infiltration mediates the association between neutrophil/lymphocyte ratio and survival in gastric cancer
por: He, Qifei, et al.
Publicado: (2023)

TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation
por: Qin, Ying, et al.
Publicado: (2021)

Clinical predictive efficacy of C-reactive protein for diagnosing infectious complications after gastric surgery
por: Shi, Jinyao, et al.
Publicado: (2020)

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
por: Fong, Ka-wing, et al.
Publicado: (2018)

EIF3B is associated with poor outcomes in gastric cancer patients and promotes cancer progression via the PI3K/AKT/mTOR signaling pathway
por: Wang, Lin, et al.
Publicado: (2019)

TRIM28 modulates nuclear receptor signaling to regulate uterine function
por: Li, Rong, et al.
Publicado: (2023)

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
por: Jiang, Xianjie, et al.
Publicado: (2019)

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope
por: Textor, Ana, et al.
Publicado: (2016)

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity
por: Dalgaard, Kevin, et al.
Publicado: (2016)

Germline mutations and somatic inactivation of TRIM28 in Wilms tumour
por: Halliday, Benjamin J., et al.
Publicado: (2018)

TRIM28 activates autophagy and promotes cell proliferation in glioblastoma
por: Peng, Yong, et al.
Publicado: (2019)

Prognostic significance of TRIM28 expression in patients with breast carcinoma
por: Zhang, Wen, et al.
Publicado: (2021)

Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein
por: Wei, Chunli, et al.
Publicado: (2016)

Anti-PD-1 Therapy Response Predicted by the Combination of Exosomal PD-L1 and CD28
por: Zhang, Chaoxu, et al.
Publicado: (2020)

S100a9 deficiency accelerates MDS-associated tumor escape via PD-1/PD-L1 overexpression: S100a9 deficiency accelerates tumor escape
por: Wang, Roujia, et al.
Publicado: (2023)

Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope
por: Textor, Ana, et al.
Publicado: (2017)

Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells
por: Song, Xiao, et al.
Publicado: (2018)

The Abundance and Diversity of Soil Fungi in Continuously Monocropped Chrysanthemum
por: Song, Aiping, et al.
Publicado: (2013)

Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements
por: Turelli, Priscilla, et al.
Publicado: (2014)

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells
por: Fasching, Liana, et al.
Publicado: (2014)

TRIM28 Selective Nanobody Reduces Glioblastoma Stem Cell Invasion
por: Porčnik, Andrej, et al.
Publicado: (2021)

Identification and validation of crucial lnc-TRIM28-14 and hub genes promoting gastric cancer peritoneal metastasis
por: Dong, Chao, et al.
Publicado: (2023)

Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis
por: Xing, Xiaofang, et al.
Publicado: (2022)

Metastatic Colonization: Escaping Immune Surveillance
por: Schaller, Julien, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ioah30ahuue2aule2im03kuiav