Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes

Hypoxia contributes to numerous pathophysiological conditions including inflammation-associated diseases. We characterized the impact of hypoxia on the immunometabolic cross-talk between cholesterol and interferon (IFN) responses. Specifically, hypoxia reduced cholesterol biosynthesis flux and provo...

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Detalles Bibliográficos
Autores principales: Bauer, Rebekka, Meyer, Sofie Patrizia, Raue, Rebecca, Palmer, Megan A., Guerrero Ruiz, Vanesa Maria, Cardamone, Giulia, Rösser, Silvia, Heffels, Milou, Roesmann, Fabian, Wilhelm, Alexander, Lütjohann, Dieter, Zarnack, Kathi, Fuhrmann, Dominik Christian, Widera, Marek, Schmid, Tobias, Brüne, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291055/
https://www.ncbi.nlm.nih.gov/pubmed/37377965
http://dx.doi.org/10.3389/fimmu.2023.1121864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291055/
https://www.ncbi.nlm.nih.gov/pubmed/37377965
http://dx.doi.org/10.3389/fimmu.2023.1121864

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