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Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides
In this work, a new series of quinoline–quinazolinone–thioacetamide derivatives 9a–p were designed using a combination of effective pharmacophores of the potent α-glucosidase inhibitors. These compounds were synthesized by simple chemical reactions and evaluated for their anti-α-glucosidase activity...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291282/ https://www.ncbi.nlm.nih.gov/pubmed/37377867 http://dx.doi.org/10.1039/d3ra01790g |
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author | Safapoor, Sajedeh Halimi, Mohammad Ghomi, Minoo Khalili Noori, Milad Dastyafteh, Navid Javanshir, Shahrzad Hosseini, Samanesadat Mojtabavi, Somayeh Faramarzi, Mohammad Ali Nasli-Esfahani, Ensieh Larijani, Bagher Fakhrioliaei, Azadeh Dekamin, Mohammad G. Mohammadi-Khanaposhtani, Maryam Mahdavi, Mohammad |
author_facet | Safapoor, Sajedeh Halimi, Mohammad Ghomi, Minoo Khalili Noori, Milad Dastyafteh, Navid Javanshir, Shahrzad Hosseini, Samanesadat Mojtabavi, Somayeh Faramarzi, Mohammad Ali Nasli-Esfahani, Ensieh Larijani, Bagher Fakhrioliaei, Azadeh Dekamin, Mohammad G. Mohammadi-Khanaposhtani, Maryam Mahdavi, Mohammad |
author_sort | Safapoor, Sajedeh |
collection | PubMed |
description | In this work, a new series of quinoline–quinazolinone–thioacetamide derivatives 9a–p were designed using a combination of effective pharmacophores of the potent α-glucosidase inhibitors. These compounds were synthesized by simple chemical reactions and evaluated for their anti-α-glucosidase activity. Among the tested compounds, compounds 9a, 9f, 9g, 9j, 9k, and 9m demonstrated significant inhibition effects in comparison to the positive control acarbose. Particularly, compound 9g with inhibitory activity around 83-fold more than acarbose exhibited the best anti-α-glucosidase activity. Compound 9g showed a competitive type of inhibition in the kinetic study, and the molecular simulation studies demonstrated that this compound with a favorable binding energy occupied the active site of α-glucosidase. Furthermore, in silico ADMET studies of the most potent compounds 9g, 9a, and 9f were performed to predict their drug-likeness, pharmacokinetic, and toxicity properties. |
format | Online Article Text |
id | pubmed-10291282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-102912822023-06-27 Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides Safapoor, Sajedeh Halimi, Mohammad Ghomi, Minoo Khalili Noori, Milad Dastyafteh, Navid Javanshir, Shahrzad Hosseini, Samanesadat Mojtabavi, Somayeh Faramarzi, Mohammad Ali Nasli-Esfahani, Ensieh Larijani, Bagher Fakhrioliaei, Azadeh Dekamin, Mohammad G. Mohammadi-Khanaposhtani, Maryam Mahdavi, Mohammad RSC Adv Chemistry In this work, a new series of quinoline–quinazolinone–thioacetamide derivatives 9a–p were designed using a combination of effective pharmacophores of the potent α-glucosidase inhibitors. These compounds were synthesized by simple chemical reactions and evaluated for their anti-α-glucosidase activity. Among the tested compounds, compounds 9a, 9f, 9g, 9j, 9k, and 9m demonstrated significant inhibition effects in comparison to the positive control acarbose. Particularly, compound 9g with inhibitory activity around 83-fold more than acarbose exhibited the best anti-α-glucosidase activity. Compound 9g showed a competitive type of inhibition in the kinetic study, and the molecular simulation studies demonstrated that this compound with a favorable binding energy occupied the active site of α-glucosidase. Furthermore, in silico ADMET studies of the most potent compounds 9g, 9a, and 9f were performed to predict their drug-likeness, pharmacokinetic, and toxicity properties. The Royal Society of Chemistry 2023-06-26 /pmc/articles/PMC10291282/ /pubmed/37377867 http://dx.doi.org/10.1039/d3ra01790g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Safapoor, Sajedeh Halimi, Mohammad Ghomi, Minoo Khalili Noori, Milad Dastyafteh, Navid Javanshir, Shahrzad Hosseini, Samanesadat Mojtabavi, Somayeh Faramarzi, Mohammad Ali Nasli-Esfahani, Ensieh Larijani, Bagher Fakhrioliaei, Azadeh Dekamin, Mohammad G. Mohammadi-Khanaposhtani, Maryam Mahdavi, Mohammad Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides |
title | Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides |
title_full | Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides |
title_fullStr | Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides |
title_full_unstemmed | Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides |
title_short | Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides |
title_sort | synthesis, admt prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291282/ https://www.ncbi.nlm.nih.gov/pubmed/37377867 http://dx.doi.org/10.1039/d3ra01790g |
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