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How chromosomal translocations arise to cause cancer: Gene proximity, trans-splicing, and DNA end joining
Chromosomal translocations (CTs) are a genetic hallmark of cancer. They could be identified as recurrent genetic aberrations in hemato-malignancies and solid tumors. More than 40% of all “cancer genes” were identified in recurrent CTs. Most of these CTs result in the production of oncofusion protein...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291325/ https://www.ncbi.nlm.nih.gov/pubmed/37378346 http://dx.doi.org/10.1016/j.isci.2023.106900 |