PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors

CDC7 kinase is crucial for DNA replication initiation and fork processing. CDC7 inhibition mildly activates the ATR pathway, which further limits origin firing; however, to date the relationship between CDC7 and ATR remains controversial. We show that CDC7 and ATR inhibitors are either synergistic o...

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Detalles Bibliográficos
Autores principales: Göder, Anja, Quinlan, Aisling, Rainey, Michael D., Bennett, Declan, Shamavu, Daniel, Corso, Jacqueline, Santocanale, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291475/
https://www.ncbi.nlm.nih.gov/pubmed/37378325
http://dx.doi.org/10.1016/j.isci.2023.106951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291475/
https://www.ncbi.nlm.nih.gov/pubmed/37378325
http://dx.doi.org/10.1016/j.isci.2023.106951

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