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PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors
CDC7 kinase is crucial for DNA replication initiation and fork processing. CDC7 inhibition mildly activates the ATR pathway, which further limits origin firing; however, to date the relationship between CDC7 and ATR remains controversial. We show that CDC7 and ATR inhibitors are either synergistic o...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291475/ https://www.ncbi.nlm.nih.gov/pubmed/37378325 http://dx.doi.org/10.1016/j.isci.2023.106951 |