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Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders
[Image: see text] Heterobifunctional PROTAC degraders are gaining attention as a differentiated therapeutic modality with the potential for oral dosing in the clinic. Belonging to the beyond Rule of Five domain of physicochemical property space, we have sought to understand the determinants of oral...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291545/ https://www.ncbi.nlm.nih.gov/pubmed/37279490 http://dx.doi.org/10.1021/acs.jmedchem.3c00740 |