Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity

[Image: see text] Proprotein convertase subtilisin/kexin 9 (PCSK9) is responsible for the degradation of the hepatic low-density lipoprotein receptor (LDLR), which regulates circulating cholesterol levels. Consequently, the PCSK9 inhibition is a valuable therapeutic approach for the treatment of hyp...

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Detalles Bibliográficos
Autores principales: Lammi, Carmen, Fassi, Enrico M. A., Manenti, Marco, Brambilla, Marta, Conti, Maria, Li, Jianqiang, Roda, Gabriella, Camera, Marina, Silvani, Alessandra, Grazioso, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291552/
https://www.ncbi.nlm.nih.gov/pubmed/37261954
http://dx.doi.org/10.1021/acs.jmedchem.3c00279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291552/
https://www.ncbi.nlm.nih.gov/pubmed/37261954
http://dx.doi.org/10.1021/acs.jmedchem.3c00279

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