Platinum(IV) Derivatives of [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells

[Image: see text] The platinum(II) complex [Pt(1S,2S-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)](2+) (Pt(II)56MeSS, 1) exhibits high potency across numerous cancer cell lines acting by a multimodal mechanism. However, 1 also displays side toxicity and in vivo activity; all details of its...

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Detalles Bibliográficos
Autores principales: Kostrhunova, Hana, McGhie, Brondwyn S., Markova, Lenka, Novakova, Olga, Kasparkova, Jana, Aldrich-Wright, Janice R., Brabec, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291556/
https://www.ncbi.nlm.nih.gov/pubmed/37285472
http://dx.doi.org/10.1021/acs.jmedchem.3c00269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291556/
https://www.ncbi.nlm.nih.gov/pubmed/37285472
http://dx.doi.org/10.1021/acs.jmedchem.3c00269

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