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AKT2-mediated nuclear deformation leads to genome instability during epithelial-mesenchymal transition

Nuclear deformation has been observed in some cancer cells for decades, but its underlying mechanism and biological significance remain elusive. To address these questions, we employed human lung cancer A549 cell line as a model in context with transforming growth factor β (TGFβ)-induced epithelial-...

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Detalles Bibliográficos
Autores principales: Fan, Jia-Rong, Chang, Sung-Nian, Chu, Ching-Tung, Chen, Hong-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291577/
https://www.ncbi.nlm.nih.gov/pubmed/37378334
http://dx.doi.org/10.1016/j.isci.2023.106992

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