CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice

The APOE4 allele increases the risk for Alzheimer’s disease (AD) in a dose-dependent manner and is also associated with cognitive decline in non-demented elderly controls. In mice with targeted gene replacement (TR) of murine APOE with human APOE3 or APOE4, the latter show reduced neuronal dendritic...

Descripción completa

Detalles Bibliográficos
Autores principales: Greco, Griffin A., Rock, Mitchell, Amontree, Matthew, Lanfranco, Maria Fe, Korthas, Holly, Hong, Sung Hyeok, Turner, R. Scott, Rebeck, G. William, Conant, Katherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291850/
https://www.ncbi.nlm.nih.gov/pubmed/36878326
http://dx.doi.org/10.1016/j.nbd.2023.106057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291850/
https://www.ncbi.nlm.nih.gov/pubmed/36878326
http://dx.doi.org/10.1016/j.nbd.2023.106057

Ejemplares similares