Cargando…

Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection

BACKGROUND & AIM: Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced by C. difficile are the major determinants of disease. However, the pathophysiological causes of diarrhea during...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peritore-Galve, F. Christopher, Kaji, Izumi, Smith, Anna, Walker, Lauren M., Shupe, John A., Washington, M. Kay, Algood, Holly M. Scott, Dudeja, Pradeep K., Goldenring, James R., Lacy, D. Borden
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291935/ https://www.ncbi.nlm.nih.gov/pubmed/37350393 http://dx.doi.org/10.1080/19490976.2023.2225841

Ejemplares similares

Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection
por: Peritore-Galve, F. Christopher, et al.
Publicado: (2022)

Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host
por: Wexler, Aaron G., et al.
Publicado: (2021)

Structural Insights into the Transition of Clostridioides difficile Binary Toxin from Prepore to Pore
por: Anderson, David M., et al.
Publicado: (2019)

Diarrhea or No Diarrhea, It Still Hurts: An Atypical Case of Clostridioides difficile
por: Singla, Abhinav, et al.
Publicado: (2020)

Fecal Microbiota of Toxigenic Clostridioides difficile-Associated Diarrhea
por: Hernández, Marta, et al.
Publicado: (2019)

Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo
por: Kordus, Shannon L., et al.
Publicado: (2023)

Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci
por: Saund, Katie, et al.
Publicado: (2022)

4345 Two-step Algorithm for Clostridioides difficile is Inadequate for Differentiating Infection from Colonization in Children
por: Nicholson, Maribeth R, et al.
Publicado: (2020)

Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolution
por: Janezic, Sandra, et al.
Publicado: (2020)

Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB
por: Childress, Kevin O., et al.
Publicado: (2023)

Characteristics of Faecal Microbiota in Korean Patients with Clostridioides difficile-associated Diarrhea
por: Jeon, Yong Duk, et al.
Publicado: (2019)

Risk Factors of Patients With Diarrhea for Having Clostridioides (Clostridium) difficile Infection
por: Lang, Vanessa, et al.
Publicado: (2022)

Nonsteroidal anti-inflammatory drugs sensitize epithelial cells to Clostridioides difficile toxin–mediated mitochondrial damage
por: Soto Ocaña, Joshua, et al.
Publicado: (2023)

Microbiota in Clostridioides difficile-Associated Diarrhea: Comparison in Recurrent and Non-Recurrent Infections
por: Gazzola, Alessandra, et al.
Publicado: (2020)

Clostridioides difficile infection in dogs with chronic-recurring diarrhea responsive to dietary changes
por: Silva, Rodrigo Otávio Silveira, et al.
Publicado: (2018)

Prevalence of Clostridioides difficile Infection in Critically Ill Patients with Extreme Leukocytosis and Diarrhea
por: Teja, Bijan, et al.
Publicado: (2021)

Effect of Genetic Diversity in Swine Leukocyte Antigen-DRA Gene on Piglet Diarrhea
por: Huang, Xiaoyu, et al.
Publicado: (2016)

Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients
por: Vázquez-Cuesta, Silvia, et al.
Publicado: (2023)

Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism
por: Chumbler, Nicole M., et al.
Publicado: (2012)

2406. Trends of Clostridioides difficile-Associated Diarrhea at a Tertiary Care Center in India
por: Khullar, Swati, et al.
Publicado: (2019)

782. Clostridioides difficile environmental contamination in hospitalized patients with diarrhea: a pilot study
por: Warren, Bobby G, et al.
Publicado: (2020)

The Impact of Infection Versus Colonization on Clostridioides difficile Environmental Contamination in Hospitalized Patients With Diarrhea
por: Warren, Bobby G, et al.
Publicado: (2022)

Clostridioides difficile Diarrhea: An Emerging Problem in a South Indian Tertiary Care Hospital
por: Kannambath, Rachana, et al.
Publicado: (2021)

Correction: Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism
por: Chumbler, Nicole M., et al.
Publicado: (2012)

Diagnostic Methods of Clostridioides difficile Infection and Clostridioides difficile Ribotypes in Studied Sample
por: Novakova, Elena, et al.
Publicado: (2021)

Iron Regulation in Clostridioides difficile
por: Berges, Mareike, et al.
Publicado: (2018)

Extraintestinal Clostridioides difficile infection
por: Hai, Zhao, et al.
Publicado: (2020)

Pathogenicity and virulence of Clostridioides difficile
por: Buddle, Jessica E., et al.
Publicado: (2023)

Predictive factors of Clostridioides difficile infection in hospitalized patients with new diarrhea: A retrospective cohort study
por: Demir, Koray K., et al.
Publicado: (2018)

792. Evaluation of Persistent Diarrhea and Recurrence Following Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection
por: Boton, Noah, et al.
Publicado: (2020)

Pediatric diarrhea patients living in urban areas have a higher incidence of Clostridioides difficile infection
por: Adesoji, Ayodele T., et al.
Publicado: (2023)

Antibiotic associated diarrhea due to Clostridioides difficile in a tertiary care teaching hospital, central India
por: Kapoor, Sunandini, et al.
Publicado: (2023)

Toward a structural understanding of Clostridium difficile toxins A and B
por: Pruitt, Rory N., et al.
Publicado: (2012)

Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection
por: Ahn, Seung Woo, et al.
Publicado: (2021)

Genes for endosomal NHE6 and NHE9 are misregulated in autism brains
por: Schwede, M, et al.
Publicado: (2014)

Plasmid-mediated metronidazole resistance in Clostridioides difficile
por: Boekhoud, Ilse M., et al.
Publicado: (2020)

688. Risk of Clostridioides difficile Infection and Antibiotic Associated Diarrhea in Patients Receiving Outpatient Parenteral Antimicrobial Therapy
por: Jaramillo, Mario, et al.
Publicado: (2023)

Metabolism the Difficile Way: The Key to the Success of the Pathogen Clostridioides difficile
por: Neumann-Schaal, Meina, et al.
Publicado: (2019)

Porcine epidemic diarrhea virus causes diarrhea by activating EGFR to regulates NHE3 activity and mobility on plasma membrane
por: Zhang, YiLing, et al.
Publicado: (2023)

Butyrate enhances Clostridioides difficile sporulation in vitro
por: Baldassare, Michelle A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_evij2fdjtikma9dj60mmjavu0g