A sensitive UPLC-MS/MS method for the simultaneous assay and trace level genotoxic impurities quantification of SARS-CoV-2 inhibitor-Molnupiravir in its pure and formulation dosage forms using fractional factorial design

Two potential genotoxic impurities were identified (PGTIs)-viz. 4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (PGTI-1), and 1-(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2,4(1H,3H)-one (PGTI-II) in the Molnupiravir (M...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakka, Srinivas, Muchakayala, Siva Krishna, Manabolu Surya, Surendra Babu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293121/
https://www.ncbi.nlm.nih.gov/pubmed/37396150
http://dx.doi.org/10.1016/j.rechem.2023.101019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293121/
https://www.ncbi.nlm.nih.gov/pubmed/37396150
http://dx.doi.org/10.1016/j.rechem.2023.101019

Ejemplares similares