Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1

cis-Aconitate decarboxylase (ACOD1, IRG1) converts cis-aconitate to the immunomodulatory and antibacterial metabolite itaconate. Although the active site residues of human and mouse ACOD1 are identical, the mouse enzyme is about fivefold more active. Aiming to identify the cause of this difference,...

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Detalles Bibliográficos
Autores principales: Chen, Fangfang, Yalcin, Israfil, Zhao, Mingming, Chen, Chutao, Blankenfeldt, Wulf, Pessler, Frank, Büssow, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293213/
https://www.ncbi.nlm.nih.gov/pubmed/37365251
http://dx.doi.org/10.1038/s41598-023-37373-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293213/
https://www.ncbi.nlm.nih.gov/pubmed/37365251
http://dx.doi.org/10.1038/s41598-023-37373-w

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