Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination

Nanoparticle (NP)-based mRNA cancer vaccines hold great promise to realize personalized cancer treatments. To advance this technology requires delivery formulations for efficient intracellular delivery to antigen-presenting cells. We developed a class of bioreducible lipophilic poly(beta-amino ester...

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Detalles Bibliográficos
Autores principales: Ben-Akiva, Elana, Karlsson, Johan, Hemmati, Shayan, Yu, Hongzhe, Tzeng, Stephany Y., Pardoll, Drew M., Green, Jordan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293809/
https://www.ncbi.nlm.nih.gov/pubmed/37339211
http://dx.doi.org/10.1073/pnas.2301606120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293809/
https://www.ncbi.nlm.nih.gov/pubmed/37339211
http://dx.doi.org/10.1073/pnas.2301606120

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