Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search

We previously demonstrated that the polycomb repressive complex 2 chromatin–modifying enzyme can directly transfer between RNA and DNA without a free-enzyme intermediate state. Simulations suggested that such a direct transfer mechanism may be generally necessary for RNA to recruit proteins to chrom...

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Detalles Bibliográficos
Autores principales: Hemphill, Wayne O., Voong, Calvin K., Fenske, Regan, Goodrich, James A., Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293810/
https://www.ncbi.nlm.nih.gov/pubmed/37339225
http://dx.doi.org/10.1073/pnas.2220537120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293810/
https://www.ncbi.nlm.nih.gov/pubmed/37339225
http://dx.doi.org/10.1073/pnas.2220537120

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