Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria

Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage of malaria infection. High plasma levels of HRPII are associated with cerebral malaria, a severe and highly fatal complication of malaria. HRPII has been shown to induce vascular leakage, the hallmark of ce...

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Detalles Bibliográficos
Autores principales: Nguyen, Suong T., Du, Daniel, Wychrij, Daniel, Cain, Matthew D., Wu, Qingping, Klein, Robyn S., Russo, Ilaria, Goldberg, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293821/
https://www.ncbi.nlm.nih.gov/pubmed/37307435
http://dx.doi.org/10.1073/pnas.2306318120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293821/
https://www.ncbi.nlm.nih.gov/pubmed/37307435
http://dx.doi.org/10.1073/pnas.2306318120

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