Cargando…
Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond
Integrin-mediated adhesion is essential for metazoan life. Integrin binding to ligand requires an activation step prior to binding ligand that depends on direct binding of talin and kindlin to the β-integrin cytoplasmic tail and the transmission of force from the actomyosin via talin to the integrin...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293852/ https://www.ncbi.nlm.nih.gov/pubmed/37339195 http://dx.doi.org/10.1073/pnas.2218116120 |