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Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway

OBJECTIVE AND BACKGROUND: The deficiency of ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) causes the phenotype similar to knee osteoarthritis (OA). However, the molecular mechanism is poorly understood. METHOD: The global deletion of Enpp1 (Enpp1(−/−)) mice was created to analyze the ro...

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Detalles Bibliográficos
Autores principales: Gao, Zhiqiang, Wang, Qiang, Guo, Kai, Li, Xinhua, Huang, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294376/
https://www.ncbi.nlm.nih.gov/pubmed/37370114
http://dx.doi.org/10.1186/s13018-023-03923-1