Cargando…

Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway

OBJECTIVE AND BACKGROUND: The deficiency of ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) causes the phenotype similar to knee osteoarthritis (OA). However, the molecular mechanism is poorly understood. METHOD: The global deletion of Enpp1 (Enpp1(−/−)) mice was created to analyze the ro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Zhiqiang, Wang, Qiang, Guo, Kai, Li, Xinhua, Huang, Yufeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294376/ https://www.ncbi.nlm.nih.gov/pubmed/37370114 http://dx.doi.org/10.1186/s13018-023-03923-1

Ejemplares similares

ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway
por: Wang, Qiang, et al.
Publicado: (2022)

Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency
por: Oheim, Ralf, et al.
Publicado: (2019)

AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes
por: Zhu, Zhenglin, et al.
Publicado: (2022)

Icariin inhibits chondrocyte apoptosis and angiogenesis by regulating the TDP‐43 signaling pathway
por: Huang, He, et al.
Publicado: (2019)

Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy
por: Li, Xiaodong, et al.
Publicado: (2017)

PSAT219 Renal Phosphate Wasting Caused by ENPP-1 mutation.
por: Madahar, Inderpreet, et al.
Publicado: (2022)

A New Enpp1 allele, Enpp1(ttw-Ham), Identified in an ICR Closed Colony
por: Takabayashi, Shuji, et al.
Publicado: (2014)

Role of ENPP1 on Adipocyte Maturation
por: Liang, Jian, et al.
Publicado: (2007)

ENPP2 Methylation in Health and Cancer
por: Panagopoulou, Maria, et al.
Publicado: (2021)

Mechanism of Action of Acupotomy in Inhibiting Chondrocyte Apoptosis in Rabbits with KOA through the PI3K/Akt Signaling Pathway
por: Huang, Xiao-shuang, et al.
Publicado: (2020)

ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1
por: Onyedibe, Kenneth I., et al.
Publicado: (2019)

Ectopic Calcification and Hypophosphatemic Rickets: Natural History of ENPP1 and ABCC6 Deficiencies
por: Ferreira, Carlos R, et al.
Publicado: (2021)

Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis
por: Chen, Yang, et al.
Publicado: (2022)

Hip Geometry Variation in Homozygous Ectonucleotide Pyrophosphatase/ Phosphodiesterase 1 (ENPP1) Deficient Patients
por: Theng, Elizabeth H, et al.
Publicado: (2021)

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway
por: Wang, Songnan, et al.
Publicado: (2023)

EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway
por: Wu, Jing, et al.
Publicado: (2019)

ENPP1 Immunobiology as a Therapeutic Target
por: Ruiz-Fernández de Córdoba, Borja, et al.
Publicado: (2023)

AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice
por: Zhou, Sheng, et al.
Publicado: (2017)

The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos
por: Massé, Karine, et al.
Publicado: (2021)

Lifelong impact of ENPP1 Deficiency and the early onset form of ABCC6 Deficiency from patient or caregiver perspective
por: O’Brien, Christine, et al.
Publicado: (2022)

Electroacupuncture inhibits sodium nitroprusside-mediated chondrocyte apoptosis through the mitochondrial pathway
por: Lin, Jie, et al.
Publicado: (2018)

17β-Estradiol Induces Mitophagy Upregulation to Protect Chondrocytes via the SIRT1-Mediated AMPK/mTOR Signaling Pathway
por: Mei, Runhong, et al.
Publicado: (2021)

Estimation of ENPP1 deficiency genetic prevalence using a comprehensive literature review and population databases
por: Chunn, Lauren M., et al.
Publicado: (2022)

Ozone induces autophagy in rat chondrocytes stimulated with IL-1β through the AMPK/mTOR signaling pathway
por: Zhao, Xu, et al.
Publicado: (2018)

ENPP1 processes protein ADP‐ribosylation in vitro
por: Palazzo, Luca, et al.
Publicado: (2016)

Ablation of Enpp6 Results in Transient Bone Hypomineralization
por: Dillon, Scott, et al.
Publicado: (2020)

Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway
por: Liu, Na, et al.
Publicado: (2020)

Arsenic Inhibits Neurite Outgrowth by Inhibiting the LKB1–AMPK Signaling Pathway
por: Wang, Xin, et al.
Publicado: (2010)

ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
por: Carozza, Jacqueline A., et al.
Publicado: (2022)

Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer
por: Hu, Changxiao, et al.
Publicado: (2021)

Crystal structures of human ENPP1 in apo and bound forms
por: Dennis, Matthew L., et al.
Publicado: (2020)

Association of the ENPP1/ENTPD1 Polymorphisms in Hemodialysis Patients
por: Zhang, Xi, et al.
Publicado: (2021)

Human antibodies targeting ENPP1 as candidate therapeutics for cancers
por: Chu, Xiaojie, et al.
Publicado: (2023)

FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway
por: Kan, Shiyi, et al.
Publicado: (2023)

MicroRNA-93 inhibits chondrocyte apoptosis and inflammation in osteoarthritis by targeting the TLR4/NF-κB signaling pathway
por: Ding, Yanjie, et al.
Publicado: (2019)

Metformin Induces Apoptosis through AMPK-Dependent Inhibition of UPR Signaling in ALL Lymphoblasts
por: Leclerc, Gilles M., et al.
Publicado: (2013)

Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate
por: Li, Yan, et al.
Publicado: (2023)

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway
por: Guo, Zhou, et al.
Publicado: (2022)

Role of the ROS/AMPK signaling pathway in tetramethylpyrazine-induced apoptosis in gastric cancer cells
por: YI, BO, et al.
Publicado: (2013)

Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis
por: Ma, Ching-Hou, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ppi567imbtgbof2dmreughqaea