Synthesis, α-Glucosidase inhibitory activity and docking studies of Novel Ethyl 1,2,3-triazol-4-ylmethylthio-5,6-diphenylpyridazine-4-carboxylate derivatives

In this work, a novel series of pyridazine-triazole hybrid molecules were prepared and evaluated as inhibitors of rat intestinal α-glucosidase enzyme. Amongst all newly synthesized compounds, 10k showed good inhibition in the series with IC(50) value of 1.7 µM which is 100 folds stronger than positi...

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Detalles Bibliográficos
Autores principales: Firoozpour, Loghman, Moghimi, Setareh, Salarinejad, Somayeh, Toolabi, Mahsa, Rafsanjani, Mahdi, Pakrad, Roya, Salmani, Farzaneh, Shokrolahi, Seyed Mohammad, Sadat Ebrahimi, Seyed Esmail, Karima, Saeed, Foroumadi, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294378/
https://www.ncbi.nlm.nih.gov/pubmed/37365646
http://dx.doi.org/10.1186/s13065-023-00973-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294378/
https://www.ncbi.nlm.nih.gov/pubmed/37365646
http://dx.doi.org/10.1186/s13065-023-00973-8

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