Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion

BACKGROUND: Platelets and erythrocytes constitute over 95% of all hematopoietic stem cell output. However, the clonal dynamics of HSC contribution to these lineages remains largely unexplored. RESULTS: We use lentiviral genetic labeling of mouse hematopoietic stem cells to quantify output from all l...

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Detalles Bibliográficos
Autores principales: Wojtowicz, Edyta E., Mistry, Jayna J., Uzun, Vladimir, Hellmich, Charlotte, Scoones, Anita, Chin, Desmond W., Kettyle, Laura M., Grasso, Francesca, Lord, Allegra M., Wright, David J., Etherington, Graham J., Woll, Petter S., Belderbos, Mirjam E., Bowles, Kristian M., Nerlov, Claus, Haerty, Wilfried, Bystrykh, Leonid V., Jacobsen, Sten Eirik W., Rushworth, Stuart A., Macaulay, Iain C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294477/
https://www.ncbi.nlm.nih.gov/pubmed/37370129
http://dx.doi.org/10.1186/s13059-023-02976-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294477/
https://www.ncbi.nlm.nih.gov/pubmed/37370129
http://dx.doi.org/10.1186/s13059-023-02976-z

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