Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular carcinoma

Nur77 modulators have emerged as a promising therapeutic approach for hepatocellular carcinoma. In this study, a structure-based rational drug design approach was used to design and synthesise a series of 4-((8-hydroxy-2-methylquinolin-4-yl)amino)benzoylhydrazone derivatives based on the binding cha...

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Detalles Bibliográficos
Autores principales: He, Fengming, Chen, Jun, Zhao, Taige, Wu, Qiaoqiong, Yin, Na, Wang, Xiumei, Zhong, Yijing, Guo, Xiaodan, Qiu, YingKun, Li, Baicun, Fang, Meijuan, Wu, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294756/
https://www.ncbi.nlm.nih.gov/pubmed/37357764
http://dx.doi.org/10.1080/14756366.2023.2227777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294756/
https://www.ncbi.nlm.nih.gov/pubmed/37357764
http://dx.doi.org/10.1080/14756366.2023.2227777

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