Cargando…

Caffeine Inhibits Oxidative Stress- and Low Dose Endotoxemia-Induced Senescence—Role of Thioredoxin-1

The maintenance of Thioredoxin-1 (Trx-1) levels, and thus of cellular redox homeostasis, is vital for endothelial cells (ECs) to prevent senescence induction. One hallmark of EC functionality, their migratory capacity, which depends on intact mitochondria, is reduced in senescence. Caffeine improves...

Descripción completa

Detalles Bibliográficos
Autores principales:	Merk, Dennis, Greulich, Jan, Vierkant, Annika, Cox, Fiona, Eckermann, Olaf, von Ameln, Florian, Dyballa-Rukes, Nadine, Altschmied, Joachim, Ale-Agha, Niloofar, Jakobs, Philipp, Haendeler, Judith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294853/ https://www.ncbi.nlm.nih.gov/pubmed/37371974 http://dx.doi.org/10.3390/antiox12061244

Ejemplares similares

CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine
por: Ale-Agha, Niloofar, et al.
Publicado: (2018)

Selenoprotein T Protects Endothelial Cells against Lipopolysaccharide-Induced Activation and Apoptosis
por: Merk, Dennis, et al.
Publicado: (2021)

Protective Effects of Curcumin in Cardiovascular Diseases—Impact on Oxidative Stress and Mitochondria
por: Cox, Fiona Frederike, et al.
Publicado: (2022)

Non-Canonical Activation of the Epidermal Growth Factor Receptor by Carbon Nanoparticles
por: Stöckmann, Daniel, et al.
Publicado: (2018)

High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells
por: Gonnissen, Stefanie, et al.
Publicado: (2019)

Non-canonical functions of Telomerase Reverse Transcriptase – Impact on redox homeostasis
por: Rosen, Julia, et al.
Publicado: (2020)

Role of Telomerase in the Cardiovascular System
por: Zurek, Mark, et al.
Publicado: (2016)

Extra-Nuclear Functions of the Transcription Factor Grainyhead-Like 3 in the Endothelium—Interaction with Endothelial Nitric Oxide Synthase
por: Jander, Kirsten, et al.
Publicado: (2021)

The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor
por: Brinkmann, Vanessa, et al.
Publicado: (2020)

Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects
por: Brinkmann, Vanessa, et al.
Publicado: (2022)

The aryl hydrocarbon receptor promotes aging phenotypes across species
por: Eckers, Anna, et al.
Publicado: (2016)

"Shping 2" different cellular localizations - a potential new player in aging processes
por: Jakob, Sascha, et al.
Publicado: (2009)

Nuclear-mitochondrial crosstalk – role in aging processes
por: Altschmied, J, et al.
Publicado: (2009)

Grainyhead like 3 – a newly identified TNFalpha regulated transcription factor – is regulated by the Src kinases & NO
por: Lukosz, M, et al.
Publicado: (2009)

Mitochondrial TERT enhances mitochondria functions in vivo by protecting mitochondrial DNA integrity from oxidative damage
por: Buechner, N, et al.
Publicado: (2009)

Accessing Mitochondrial Protein Import in Living Cells by Protein Microinjection
por: Bogorodskiy, Andrey, et al.
Publicado: (2021)

Nuclear Shp-2 keeps telomerase reverse transcriptase in the nucleus – new potential anti-aging target
por: Jakob, S, et al.
Publicado: (2009)

Downregulation of ETS Rescues Diabetes-Induced Reduction of Endothelial Progenitor Cells
por: Seeger, Florian Hartmut, et al.
Publicado: (2009)

Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target
por: El Hadri, Khadija, et al.
Publicado: (2021)

Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases
por: Bogorodskiy, Andrey, et al.
Publicado: (2021)

Hyperinflammation, T cells, and endotoxemia
por: Inoue, Makoto, et al.
Publicado: (2015)

ODP251 Thioredoxin-Interacting Protein (Txnip) And Cellular Senescence: Potential Adverse Effects of Txnip Deficiency.
por: Abubaker, Mohammed, et al.
Publicado: (2022)

The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein
por: Hwang, Jungwon, et al.
Publicado: (2014)

Thioredoxin Profiling of Multiple Thioredoxin-Like Proteins in Staphylococcus aureus
por: Peng, Hui, et al.
Publicado: (2018)

Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy
por: Li, Yi-Fang, et al.
Publicado: (2018)

Selenium Concentrations for Maximisation of Thioredoxin Reductase 2 Activity and Upregulation of Its Gene Transcripts in Senescent Human Fibroblasts
por: Ghneim, Hazem K.
Publicado: (2017)

Thioredoxin and Cancer: A Role for Thioredoxin in all States of Tumor Oxygenation
por: Karlenius, Therese Christina, et al.
Publicado: (2010)

Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer
por: Uccella, S, et al.
Publicado: (2013)

Long-Term IGF1 Stimulation Leads to Cellular Senescence via Functional Interaction with the Thioredoxin-Interacting Protein, TXNIP
por: Nagaraj, Karthik, et al.
Publicado: (2022)

Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure‐Overloaded Hearts
por: Nguyen, T. Dung, et al.
Publicado: (2018)

Effects of tigecycline and doxycycline in porcine endotoxemia
por: Von Seth, M, et al.
Publicado: (2011)

Endotoxemia is associated with an adverse metabolic profile
por: Määttä, Anne-Mari, et al.
Publicado: (2020)

The Importance of Food for Endotoxemia and an Inflammatory Response
por: Erlanson-Albertsson, Charlotte, et al.
Publicado: (2021)

Lung protective effect of Ticagrelor in endotoxemia
por: Mueen, Ruaa Murtada, et al.
Publicado: (2023)

Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer
por: Cadenas, Cristina, et al.
Publicado: (2010)

Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation
por: Thompson, Joyce K, et al.
Publicado: (2014)

Cell Signaling with Extracellular Thioredoxin and Thioredoxin-Like Proteins: Insight into Their Mechanisms of Action
por: Léveillard, Thierry, et al.
Publicado: (2017)

Expression of Thioredoxin/Thioredoxin Reductase System Genes in Aphid-Challenged Maize Seedlings
por: Sytykiewicz, Hubert, et al.
Publicado: (2020)

Oxidative regulation of chloroplast enzymes by thioredoxin and thioredoxin-like proteins in Arabidopsis thaliana
por: Yokochi, Yuichi, et al.
Publicado: (2021)

Effects of caffeine on the detection of ischemia in patients undergoing adenosine stress cardiovascular magnetic resonance imaging
por: Greulich, Simon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_vtc8goq3lhme9l9anaqf479jh1