Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress

Tightly regulated and robust mitochondrial activities are critical for normal hearing. Previously, we demonstrated that Fus1/Tusc2 KO mice with mitochondrial dysfunction exhibit premature hearing loss. Molecular analysis of the cochlea revealed hyperactivation of the mTOR pathway, oxidative stress,...

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Detalles Bibliográficos
Autores principales: Tan, Winston J. T., Santos-Sacchi, Joseph, Tonello, Jane, Shanker, Anil, Ivanova, Alla V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294946/
https://www.ncbi.nlm.nih.gov/pubmed/37371955
http://dx.doi.org/10.3390/antiox12061225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294946/
https://www.ncbi.nlm.nih.gov/pubmed/37371955
http://dx.doi.org/10.3390/antiox12061225

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