Microenvironmental mechanoactivation through Yap/Taz suppresses chondrogenic gene expression

Chondrocyte phenotype is preserved when cells are round and the actin cytoskeleton is cortical. Conversely, these cells rapidly dedifferentiate in vitro with increased mechanoactive Rho signaling, which increases cell size and causes large actin stress fiber to form. While the effects of Rho on chon...

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Detalles Bibliográficos
Autores principales: Hallström, Grey F., Jones, Dakota L., Locke, Ryan C., Bonnevie, Edward D., Kim, Sung Yeon, Laforest, Lorielle, Garcia, Diana Cruz, Mauck, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295477/
https://www.ncbi.nlm.nih.gov/pubmed/37043309
http://dx.doi.org/10.1091/mbc.E22-12-0543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295477/
https://www.ncbi.nlm.nih.gov/pubmed/37043309
http://dx.doi.org/10.1091/mbc.E22-12-0543

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