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Glutamylation is a negative regulator of microtubule growth

Microtubules are noncovalent polymers built from αβ-tubulin dimers. The disordered C-terminal tubulin tails are functionalized with multiple glutamate chains of variable lengths added and removed by tubulin tyrosine ligases (TTLLs) and carboxypeptidases (CCPs). Glutamylation is abundant on stable mi...

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Detalles Bibliográficos
Autores principales: Chen, Jiayi, Roll-Mecak, Antonina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295482/
https://www.ncbi.nlm.nih.gov/pubmed/37074962
http://dx.doi.org/10.1091/mbc.E23-01-0030